C1RL

Across TCGA cell cohorts, C1RL RNA expression is significantly associated with the go_rna of many other GO terms, with 5,680 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible C1RL-associated GO terms across cancer lineages are Fatty acid beta-oxidation, Striated muscle contraction, and Complement activation, classical pathway. Each is linked with C1RL in more than 12 cancer types. Because this analysis shows association rather than direction, both C1RL-to-partner and partner-to-C1RL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fatty acid beta-oxidation grouped by C1RL-low versus C1RL-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C1RL→partner) and Y-score (partner→C1RL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Fatty acid beta-oxidation →	+0.120	+1.612	<.001	.008	3	13
SOFT_TISSUE	Striated muscle contraction →	+0.101	+2.226	<.001	<.001	3	12
BONE	Complement activation, classical pathway →	+1.575	+2.089	<.001	.002	3	12
OESOPHAGUS	Regulation of myoblast fusion →	+0.118	+1.036	<.001	.002	3	12
LARGE_INTESTINE	Negative regulation of myoblast fusion →	+0.115	+0.957	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.102	+1.130	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,680 associations by consensus.

Fatty acid beta-oxidation by C1RL expression — LIVER

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