C1RL

Across TCGA cell cohorts, C1RL mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C1RL-associated genes across cancer lineages are CSN2, FAM205A, and USP26. Each is linked with C1RL in more than 1 cancer types. Because this analysis shows association rather than direction, both C1RL-to-partner and partner-to-C1RL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by C1RL-low versus C1RL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1RL→partner) and Y-score (partner→C1RL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CSN2 →	+0.052	+5.415	.009	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.028	+4.029	<.001	<.001	3	1
LARGE_INTESTINE	USP26 →	+0.045	+2.836	.005	.009	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CSN2 by C1RL expression — SKIN

Explore this box plot interactively →