C1R

Across TCGA pan-cancer cohorts, C1R mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C1R data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher C1R mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C1R expression acts as an unfavorable survival marker.

COAD, UCEC, and LUAD are the cancer types where C1R mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.882	1.000	.016	36	view →
UCEC	DFS	Median	III,IV	0.424	1.000	.003	30	view →
LUAD	OS	Tertile	III,IV	0.424	0.879	.006	18	view →
GBM	DFS	Tertile	All	0.225	0.499	.002	15	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	12	view →
PDAC	DFS	Tertile	IV	0.217	0.654	.010	9	view →
LSCC	OS	Median	II,III,IV	0.901	1.000	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C1R–COAD (DFS)

Open the COAD breakdown →