C1R

Across TCGA patient cohorts, C1R mutation is significantly associated with the RNA expression of many other genes, with 2,547 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1R-associated genes across cancer lineages are TAF9, IFNW1, and PSMD7P1. Each is linked with C1R in more than 1 cancer types. Because this analysis shows association rather than direction, both C1R-to-partner and partner-to-C1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF9 grouped by C1R-low versus C1R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1R→partner) and Y-score (partner→C1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF9 →	+0.730	+2.643	<.001	<.001	3	2
LIHC	IFNW1 →	+0.038	+4.174	<.001	.003	3	2
SKCM	PSMD7P1 →	+0.063	+2.159	.001	<.001	3	2
UCEC	MED27 →	+0.300	+2.406	.007	.002	3	2
UCEC	URM1 →	+0.388	+2.992	<.001	<.001	3	2
UCEC	NCAPH2 →	+0.444	+2.694	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,547 associations by consensus.

TAF9 by C1R expression — UCEC

Explore this box plot interactively →