C1R

Across TCGA patient cohorts, C1R mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1R-associated genes across cancer lineages are ERK2, GAPDH, and PEA-15_pS116. Each is linked with C1R in more than 1 cancer types. Because this analysis shows association rather than direction, both C1R-to-partner and partner-to-C1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by C1R-low versus C1R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1R→partner) and Y-score (partner→C1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.225	+3.584	<.001	.002	3	2
UCEC	GAPDH →	+0.500	+2.000	.008	.009	3	2
UCEC	PEA-15_pS116 →	+0.326	+1.362	.008	.037	3	2
UCEC	Shc_pY317 →	-0.147	-1.584	.006	.034	3	2
UCEC	TIGAR →	+0.136	+1.689	.011	.007	3	2
UCEC	Tuberin_pT1462 →	+0.229	+1.687	.005	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ERK2 by C1R expression — UCEC

Explore this box plot interactively →