C1R

Across TCGA cell cohorts, C1R RNA expression is significantly associated with the go_rna of many other GO terms, with 5,886 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible C1R-associated GO terms across cancer lineages are Complement activation, classical pathway, Response to hydrostatic pressure, and Protein targeting to lysosome involved in chaperone-mediated autophagy. Each is linked with C1R in more than 16 cancer types. Because this analysis shows association rather than direction, both C1R-to-partner and partner-to-C1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement activation, classical pathway grouped by C1R-low versus C1R-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C1R→partner) and Y-score (partner→C1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Complement activation, classical pathway →	+2.055	+3.382	<.001	<.001	3	17
BONE	Response to hydrostatic pressure →	+0.192	+2.604	.001	.003	3	14
OESOPHAGUS	Protein targeting to lysosome involved in chaperone-mediated autophagy →	+0.194	+2.830	<.001	.004	2	15
SKIN	Regulation of intracellular transport →	+0.051	+1.490	.003	.005	3	14
KIDNEY	Negative regulation of protein catabolic process →	+0.070	+2.472	.001	.005	3	13
LIVER	Humoral immune response mediated by circulating immunoglobulin →	+0.450	+3.934	.001	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,886 associations by consensus.

Complement activation, classical pathway by C1R expression — LUNG_NSCLC_LUSC

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