C1R

Across TCGA cell cohorts, C1R mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C1R-associated genes across cancer lineages are OR2D3, CEACAM16, and PDE6C. Each is linked with C1R in more than 1 cancer types. Because this analysis shows association rather than direction, both C1R-to-partner and partner-to-C1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D3 grouped by C1R-low versus C1R-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1R→partner) and Y-score (partner→C1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2D3 →	+0.018	+2.832	.002	.002	3	1
LARGE_INTESTINE	CEACAM16 →	+0.050	+2.648	.002	.008	3	1
LARGE_INTESTINE	PDE6C →	+0.208	+3.273	.004	.006	3	1
BLOOD_Leukemia	C20orf85 →	+0.042	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SOX14 →	+0.007	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	MUC7 →	+0.223	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR2D3 by C1R expression — LARGE_INTESTINE

Explore this box plot interactively →