C1QTNF4

Across TCGA patient cohorts, C1QTNF4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1QTNF4-associated genes across cancer lineages are NF2, PDK1, and AMPK_pT172. Each is linked with C1QTNF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1QTNF4-to-partner and partner-to-C1QTNF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by C1QTNF4-low versus C1QTNF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1QTNF4→partner) and Y-score (partner→C1QTNF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.345	+3.169	.002	.019	3	1
UCEC	PDK1 →	+0.111	+3.321	.049	.010	3	1
UCEC	AMPK_pT172 →	+0.487	+2.183	.023	.035	3	1
UCEC	TIGAR →	+0.230	+2.196	.004	.034	3	1
UCEC	Fibronectin →	-0.386	-3.160	.025	.019	2	1
UCEC	p62 Lck ligand →	+0.502	+2.817	.003	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

NF2 by C1QTNF4 expression — UCEC

Explore this box plot interactively →