C1QL3

Across TCGA patient cohorts, C1QL3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1QL3-associated genes across cancer lineages are ER-alpha, JNK2, and Ku80. Each is linked with C1QL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1QL3-to-partner and partner-to-C1QL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by C1QL3-low versus C1QL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1QL3→partner) and Y-score (partner→C1QL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	+0.719	+2.321	.034	.034	3	1
UCEC	JNK2 →	+0.226	+2.321	.005	.006	3	1
UCEC	Ku80 →	+0.338	+3.013	<.001	<.001	3	1
UCEC	MIG-6 →	-0.126	-2.999	.002	.035	3	1
UCEC	p90 RSK →	+0.168	+2.331	.033	.019	3	1
UCEC	PDK1_pS241 →	+0.163	+3.321	.020	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ER-alpha by C1QL3 expression — UCEC

Explore this box plot interactively →