C1QL1

Across TCGA pan-cancer cohorts, C1QL1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C1QL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C1QL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C1QL1 is over-expressed in tumor, although a few such as STAD and BLCA show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where C1QL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1QL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+3.497	<.001	12	view →
HNSC	Female	III,IV	+1.954	<.001	12	view →
THCA	Female	II,III,IV	+2.307	<.001	9	view →
LUSC	Female	All	+1.980	<.001	9	view →
LIHC	Female	All	+2.795	<.001	7	view →
LUAD	All	All	+0.621	<.001	7	view →
STAD	Male	All	−1.620	<.001	6	view →
BLCA	All	All	−1.642	<.001	5	view →
COAD	Male	All	−1.086	<.001	5	view →
READ	All	All	−0.823	.019	3	view →
PRAD	All	All	−1.334	<.001	2	view →
CHOL	All	All	+1.911	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C1QL1–KIRC

Open the KIRC breakdown →