C1QC

Across TCGA pan-cancer cohorts, C1QC mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of C1QC’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where C1QC mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C1QC is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

CCRCC, LUAD, and COAD are the cancer types where C1QC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1QC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	II,III,IV	+0.549	<.001	11	view →
LUAD	Female	II,III,IV	−0.484	<.001	9	view →
COAD	Male	All	−0.468	<.001	9	view →
HNSC	Male	All	−0.536	<.001	8	view →
LSCC	Female	All	−0.488	<.001	7	view →
PDAC	Female	All	+0.870	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

C1QC–CCRCC

Open the CCRCC breakdown →