C1QC

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, C1QC protein abundance is significantly associated with the RNA expression of many other genes, with 14,889 significant associations in total. GBM shows the largest number of these associations.

The most reproducible C1QC-associated genes across cancer lineages are COL1A1, FN1, and INHBA. Each is linked with C1QC in more than 8 cancer types. Because this analysis shows association rather than direction, both C1QC-to-partner and partner-to-C1QC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C1QC versus COL1A1 in OV, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1QC→partner) and Y-score (partner→C1QC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVCOL1A1 →+2.468+0.799<.001<.00139
OVFN1 →+2.302+0.806<.001<.00139
OVINHBA →+2.237+0.740<.001<.00139
OVCOL5A1 →+1.942+0.681<.001<.00139
CCRCCGFPT2 →+1.523+0.891<.001<.00139
OVSFRP2 →+3.539+0.571<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 14,889 associations by consensus.

C1QC vs COL1A1 — OV

Per-sample scatter of C1QC vs COL1A1 in OV (Pearson r = 0.57).

Explore this scatter interactively →

Exploration