C1QC

Across TCGA cell cohorts, C1QC RNA expression is significantly associated with the go_rna of many other GO terms, with 825 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible C1QC-associated GO terms across cancer lineages are Positive regulation of Wnt protein secretion, Ubiquitin recycling, and Positive regulation of protein localization to chromatin. Each is linked with C1QC in more than 3 cancer types. Because this analysis shows association rather than direction, both C1QC-to-partner and partner-to-C1QC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of Wnt protein secretion grouped by C1QC-low versus C1QC-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C1QC→partner) and Y-score (partner→C1QC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of Wnt protein secretion →	-0.082	-0.012	<.001	<.001	3	4
SKIN	Ubiquitin recycling →	+0.065	+0.018	<.001	<.001	3	3
SKIN	Positive regulation of protein localization to chromatin →	-0.114	-0.010	<.001	.001	3	3
SKIN	Cytoplasm protein quality control →	-0.098	-0.014	<.001	.004	3	3
SKIN	Response to dehydroepiandrosterone →	-0.382	-0.012	<.001	.002	3	3
SKIN	Response to forskolin →	-0.108	-0.010	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 825 associations by consensus.

Positive regulation of Wnt protein secretion by C1QC expression — SKIN

Explore this box plot interactively →