C1QC

Across TCGA cell cohorts, C1QC mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C1QC-associated genes across cancer lineages are DAZ2, CT47A6, and OR4K2. Each is linked with C1QC in more than 1 cancer types. Because this analysis shows association rather than direction, both C1QC-to-partner and partner-to-C1QC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ2 grouped by C1QC-low versus C1QC-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1QC→partner) and Y-score (partner→C1QC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DAZ2 →	+0.106	+5.807	<.001	.001	3	1
OVARY	CT47A6 →	+0.030	+5.807	<.001	.001	3	1
BLOOD_Leukemia	OR4K2 →	+0.042	+5.969	<.001	.001	3	1
BLOOD_Leukemia	H2AP →	+0.101	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR11H2 →	+0.060	+5.201	<.001	.006	3	1
SKIN	RBMY1F →	+0.086	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

DAZ2 by C1QC expression — OVARY

Explore this box plot interactively →