C1QBP

Across TCGA pan-cancer cohorts, C1QBP mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C1QBP data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher C1QBP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C1QBP expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where C1QBP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.868	0.496	.004	33	view →
PDAC	DFS	Median	All	0.503	0.312	.002	31	view →
CCRCC	DFS	Median	II,III,IV	0.428	0.780	.001	21	view →
COAD	DFS	Median	III,IV	1.000	0.891	.032	18	view →
UCEC	OS	Median	III,IV	0.884	0.492	.031	4	view →
HNSC	OS	Median	II,III,IV	0.912	0.794	.048	1	view →
LUAD	OS	Median	II,III,IV	0.998	0.864	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C1QBP–LSCC (DFS)

Open the LSCC breakdown →