C1QB

Across TCGA pan-cancer cohorts, C1QB mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated C1QB data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher C1QB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C1QB expression acts as an unfavorable survival marker.

COAD, PDAC, and LUAD are the cancer types where C1QB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.877	1.000	.016	90	view →
PDAC	OS	Quartile	All	0.343	0.690	<.001	46	view →
LUAD	OS	Quartile	III,IV	0.270	0.784	.005	19	view →
HNSC	DFS	Quartile	II,III,IV	0.532	0.793	.018	16	view →
CCRCC	DFS	Median	III,IV	0.399	0.932	.022	16	view →
UCEC	DFS	Median	All	0.843	0.966	.005	14	view →
GBM	OS	Median	All	0.263	0.548	.002	6	view →
LSCC	OS	Median	All	0.933	1.000	.006	5	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

C1QB–COAD (DFS)

Open the COAD breakdown →