C1QB

Across TCGA cell cohorts, C1QB RNA expression is significantly associated with the go_rna of many other GO terms, with 256 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible C1QB-associated GO terms across cancer lineages are Regulation of telomeric loop disassembly, Putrescine transport, and Negative regulation of nodal signaling pathway. Each is linked with C1QB in more than 1 cancer types. Because this analysis shows association rather than direction, both C1QB-to-partner and partner-to-C1QB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomeric loop disassembly grouped by C1QB-low versus C1QB-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C1QB→partner) and Y-score (partner→C1QB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of telomeric loop disassembly →	-0.073	-0.025	.006	.001	3	2
SKIN	Putrescine transport →	+0.161	+0.025	<.001	.007	3	2
SKIN	Negative regulation of nodal signaling pathway →	-0.168	-0.028	<.001	.002	3	2
SKIN	Fatty acid transmembrane transport →	-0.084	-0.048	.004	.005	3	2
SKIN	Regulation of aggrephagy →	-0.084	-0.046	.006	.008	3	2
SKIN	Actomyosin contractile ring assembly actin filament organization →	-0.144	-0.026	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 256 associations by consensus.

Regulation of telomeric loop disassembly by C1QB expression — LARGE_INTESTINE

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