C1QB

Across TCGA cell cohorts, C1QB mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible C1QB-associated genes across cancer lineages are KCNA6, ACKR1, and OR6K6. Each is linked with C1QB in more than 1 cancer types. Because this analysis shows association rather than direction, both C1QB-to-partner and partner-to-C1QB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA6 grouped by C1QB-low versus C1QB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1QB→partner) and Y-score (partner→C1QB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KCNA6 →	+0.083	+4.108	<.001	.008	3	1
LARGE_INTESTINE	ACKR1 →	+0.065	+4.032	<.001	.004	3	1
SKIN	OR6K6 →	+0.019	+5.415	<.001	.004	3	1
SKIN	MBD3L5 →	+0.022	+5.415	<.001	.004	3	1
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1
SKIN	GH1 →	+0.049	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

KCNA6 by C1QB expression — LARGE_INTESTINE

Explore this box plot interactively →