C1GALT1

Across TCGA pan-cancer cohorts, C1GALT1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C1GALT1 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C1GALT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C1GALT1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

HNSC, UCEC, and BLCA are the cancer types where C1GALT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.155	0.656	.022	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BLCA	DFS	Median	All	0.182	0.510	.048	3	view →
SKCM	DFS	Median	II,III,IV	1.000	0.547	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C1GALT1–HNSC (OS)

Open the HNSC breakdown →