Across TCGA pan-cancer cohorts, C1D mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C1D data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher C1D mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C1D expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, COAD, and HNSC are the cancer types where C1D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.811	0.555	.011	14	view →
COAD	DFS	Median	IV	0.260	0.957	.045	6	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	6	view →
PDAC	DFS	Median	IV	0.749	0.217	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: C1D tumor-vs-normal RNA expression · all C1D data types