Across TCGA patient cohorts, C1D protein abundance is significantly associated with the RNA expression of many other genes, with 6,271 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C1D-associated genes across cancer lineages are PPM1G, FANCD2, and CHAF1B. Each is linked with C1D in more than 2 cancer types. Because this analysis shows association rather than direction, both C1D-to-partner and partner-to-C1D results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1D→partner) and Y-score (partner→C1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPM1G →	+0.537	+0.331	<.001	<.001	3	3
LSCC	FANCD2 →	+0.515	+0.240	<.001	<.001	3	3
LSCC	CHAF1B →	+0.760	+0.295	<.001	<.001	3	3
LSCC	THAP5P1 →	+0.796	+0.248	<.001	.001	3	3
HNSC	DFFA →	+0.729	+0.209	.005	.001	3	3
UCEC	TDP1 →	+0.472	+0.216	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,271 associations by consensus.

Exploration

C1D survival (RNA) · tumor vs normal (RNA) · all C1D data types