Across TCGA patient cohorts, C1D mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1D-associated genes across cancer lineages are MEK1, c-Met_pY1235, and 4E-BP1_pT37_T46. Each is linked with C1D in more than 1 cancer types. Because this analysis shows association rather than direction, both C1D-to-partner and partner-to-C1D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1D→partner) and Y-score (partner→C1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.479	+3.321	.006	.010	3	1
UCEC	c-Met_pY1235 →	+0.075	+3.179	.036	.010	3	1
UCEC	4E-BP1_pT37_T46 →	-0.450	-2.459	.013	.020	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

C1D survival (RNA) · tumor vs normal (RNA) · all C1D data types