Across TCGA pan-cancer cohorts, C19orf73 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated C19orf73 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher C19orf73 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C19orf73 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

KIRC, MESO, and HNSC are the cancer types where C19orf73 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.754	0.849	<.001	134	view →
MESO	DFS	Median	All	0.278	0.488	.003	65	view →
HNSC	OS	Median	II,III,IV	0.796	0.688	.001	48	view →
PAAD	OS	Median	II,III,IV	0.601	0.246	.003	40	view →
ACC	OS	Median	II,III,IV	0.758	0.941	.003	36	view →
UCS	DFS	Tertile	IV	0.484	0.996	.024	30	view →
UVM	DFS	Tertile	All	0.769	0.391	.004	30	view →
LIHC	DFS	Median	All	0.215	0.360	.005	19	view →
SKCM	OS	Quartile	All	0.829	0.953	.002	16	view →
KICH	DFS	Tertile	II,III,IV	1.000	0.274	.008	14	view →
DLBC	DFS	Tertile	All	0.984	0.557	.038	12	view →
LUSC	OS	Tertile	All	0.816	0.685	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: C19orf73 tumor-vs-normal RNA expression · all C19orf73 data types