Across TCGA pan-cancer cohorts, C19orf54 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C19orf54 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C19orf54 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated C19orf54 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where C19orf54 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.946	0.451	<.001	33	view →
PDAC	DFS	Tertile	All	0.219	0.946	.024	20	view →
CCRCC	DFS	Quartile	All	0.950	0.677	.012	18	view →
LSCC	OS	Tertile	All	0.940	1.000	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: C19orf54 tumor-vs-normal RNA expression · all C19orf54 data types