Across TCGA patient cohorts, C19orf54 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C19orf54-associated genes across cancer lineages are FOXO3a_pS318_S321, Notch1, and p38-MAPK_pT180_Y182. Each is linked with C19orf54 in more than 1 cancer types. Because this analysis shows association rather than direction, both C19orf54-to-partner and partner-to-C19orf54 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf54→partner) and Y-score (partner→C19orf54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.159	-3.160	.015	.019	3	1
UCEC	Notch1 →	+0.216	+3.321	.003	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.852	-3.169	<.001	.019	3	1
UCEC	PCNA →	+0.373	+3.000	<.001	.036	3	1
UCEC	PKC-delta_pS664 →	-0.184	-3.160	.003	.019	3	1
UCEC	Smad3 →	+0.216	+3.000	.006	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

C19orf54 survival (RNA) · tumor vs normal (RNA) · all C19orf54 data types