C19orf53

Across TCGA pan-cancer cohorts, C19orf53 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C19orf53 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher C19orf53 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated C19orf53 expression acts as an unfavorable survival marker.

SKCM, COAD, and LIHC are the cancer types where C19orf53 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.088	0.737	<.001	18	view →
COAD	OS	Median	All	0.001	0.871	<.001	15	view →
LIHC	DFS	Median	All	0.094	0.526	.017	9	view →
SARC	DFS	Median	All	0.149	0.613	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C19orf53–SKCM (DFS)

Open the SKCM breakdown →