C19orf53

Across TCGA patient cohorts, C19orf53 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C19orf53-associated genes across cancer lineages are MIR139, ELOCP7, and XKRYP1. Each is linked with C19orf53 in more than 1 cancer types. Because this analysis shows association rather than direction, both C19orf53-to-partner and partner-to-C19orf53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR139 grouped by C19orf53-low versus C19orf53-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf53→partner) and Y-score (partner→C19orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR139 →	+0.516	+7.731	<.001	.009	3	1
BRCA	ELOCP7 →	+0.229	+8.055	<.001	.007	3	1
BRCA	XKRYP1 →	+0.099	+8.471	<.001	.005	3	1
UCEC	RNU4-4P →	+0.840	+5.193	<.001	<.001	3	1
UCEC	RNY1P8 →	+0.949	+4.868	<.001	.004	3	1
UCEC	SNORD116-23 →	+0.967	+3.847	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MIR139 by C19orf53 expression — BRCA

Explore this box plot interactively →