C19orf53

Across TCGA cell cohorts, C19orf53 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,772 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible C19orf53-associated GO terms across cancer lineages are Regulation of glycolytic process through fructose-6-phosphate, Negative regulation of glycolytic process through fructose-6-phosphate, and [2Fe-2S] cluster assembly. Each is linked with C19orf53 in more than 15 cancer types. Because this analysis shows association rather than direction, both C19orf53-to-partner and partner-to-C19orf53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of glycolytic process through fructose-6-phosphate grouped by C19orf53-low versus C19orf53-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf53→partner) and Y-score (partner→C19orf53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of glycolytic process through fructose-6-phosphate →	+0.215	+0.846	<.001	<.001	3	16
LIVER	Negative regulation of glycolytic process through fructose-6-phosphate →	+0.215	+0.846	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	[2Fe-2S] cluster assembly →	+0.128	+1.021	<.001	<.001	3	12
SKIN	7-methylguanosine cap hypermethylation →	+0.099	+1.002	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Inner mitochondrial membrane organization →	+0.074	+0.874	<.001	<.001	3	10
PANCREAS	Negative regulation of protein localization to chromatin →	+0.126	+0.861	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,772 associations by consensus.

Regulation of glycolytic process through fructose-6-phosphate by C19orf53 expression — LIVER

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