C18orf32

Across TCGA pan-cancer cohorts, C18orf32 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated C18orf32 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher C18orf32 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C18orf32 expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

SCLC, KIRC, and MESO are the cancer types where C18orf32 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	III,IV	0.263	0.743	<.001	77	view →
KIRC	DFS	Median	All	0.712	0.548	<.001	74	view →
MESO	OS	Quartile	All	0.691	0.357	<.001	61	view →
UVM	DFS	Quartile	III,IV	0.193	0.814	.003	43	view →
THYM	DFS	Median	All	0.953	0.790	.002	31	view →
PAAD	DFS	Quartile	All	0.460	0.174	.002	30	view →
UCEC	DFS	Quartile	II,III,IV	0.890	0.760	.008	26	view →
LGG	DFS	Quartile	All	0.896	0.743	<.001	26	view →
ACC	DFS	Tertile	All	0.210	0.692	.001	20	view →
LIHC	OS	Tertile	II,III,IV	0.875	0.662	.006	20	view →
KIRP	OS	Median	All	0.972	0.889	.001	20	view →
LUAD	DFS	Tertile	IV	0.239	0.896	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

C18orf32–SCLC (DFS)

Open the SCLC breakdown →