C18orf21

Across TCGA patient cohorts, C18orf21 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C18orf21-associated genes across cancer lineages are Heregulin, INPP4B, and MEK1. Each is linked with C18orf21 in more than 1 cancer types. Because this analysis shows association rather than direction, both C18orf21-to-partner and partner-to-C18orf21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by C18orf21-low versus C18orf21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C18orf21→partner) and Y-score (partner→C18orf21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.160	-3.156	.007	.018	3	1
UCEC	INPP4B →	-0.418	-3.321	.007	.009	3	1
UCEC	MEK1 →	+0.362	+2.459	.040	.020	3	1
UCEC	p62 Lck ligand →	+0.579	+3.009	<.001	.019	3	1
UCEC	S6_pS240_S244 →	+0.475	+2.820	.015	.035	3	1
UCEC	Tuberin →	+0.434	+2.179	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Heregulin by C18orf21 expression — UCEC

Explore this box plot interactively →