C17orf78

Across TCGA patient cohorts, C17orf78 mutation is significantly associated with the RNA expression of many other genes, with 619 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C17orf78-associated genes across cancer lineages are RNA5SP248, MIR1291, and OR2AP1. Each is linked with C17orf78 in more than 1 cancer types. Because this analysis shows association rather than direction, both C17orf78-to-partner and partner-to-C17orf78 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP248 grouped by C17orf78-low versus C17orf78-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C17orf78→partner) and Y-score (partner→C17orf78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP248 →	+0.365	+2.334	<.001	.003	3	2
UCEC	MIR1291 →	+0.796	+3.721	<.001	<.001	3	1
UCEC	OR2AP1 →	+0.040	+2.977	.007	.009	3	1
UCEC	FCER1A →	-0.908	-3.700	.002	.001	3	1
UCEC	TMEM150B →	+1.017	+3.353	<.001	.005	3	1
UCEC	CCDC43 →	+0.515	+2.617	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 619 associations by consensus.

RNA5SP248 by C17orf78 expression — UCEC

Explore this box plot interactively →