C17orf78

Across TCGA patient cohorts, C17orf78 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C17orf78-associated genes across cancer lineages are EGFR_pY1068, Heregulin, and INPP4B. Each is linked with C17orf78 in more than 1 cancer types. Because this analysis shows association rather than direction, both C17orf78-to-partner and partner-to-C17orf78 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by C17orf78-low versus C17orf78-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C17orf78→partner) and Y-score (partner→C17orf78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.302	-3.459	.016	.005	3	1
UCEC	Heregulin →	-0.135	-3.000	.029	.036	3	1
UCEC	INPP4B →	-0.385	-2.999	.017	.035	3	1
UCEC	MSH6 →	-0.427	-2.321	.010	.035	3	1
UCEC	N-Ras →	-0.120	-2.308	.044	.036	3	1
UCEC	Shc_pY317 →	-0.243	-2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1068 by C17orf78 expression — UCEC

Explore this box plot interactively →