C17orf75

Across TCGA pan-cancer cohorts, C17orf75 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of C17orf75’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where C17orf75 RNA is repressed in tumor relative to normal tissue. In most cancer types C17orf75 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, HNSC, and THCA are the cancer types where C17orf75 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C17orf75 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.359	<.001	10	view →
HNSC	Male	IV	+0.849	<.001	10	view →
THCA	Male	IV	−0.736	<.001	9	view →
COAD	Female	II,III,IV	+0.711	<.001	9	view →
LIHC	Male	All	+0.815	<.001	8	view →
LUAD	Male	All	+0.506	<.001	8	view →
BLCA	All	All	+0.653	<.001	6	view →
KIRC	Male	II,III,IV	−0.394	<.001	6	view →
LUSC	Female	All	+0.808	<.001	5	view →
READ	Male	All	+0.679	.006	4	view →
STAD	All	II,III,IV	+0.442	.015	4	view →
BRCA	All	II,III,IV	+0.221	.017	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

C17orf75–KICH

Open the KICH breakdown →