C17orf75

Across TCGA pan-cancer cohorts, C17orf75 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of C17orf75’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where C17orf75 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C17orf75 is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where C17orf75 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C17orf75 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.597	<.001	10	view →
LUAD	Male	All	+0.548	<.001	9	view →
LSCC	Male	All	+0.549	<.001	8	view →
HNSC	Male	III,IV	+0.335	<.001	8	view →
PDAC	Female	All	−0.464	<.001	6	view →
OV	All	All	+0.331	.048	2	view →
CCRCC	All	All	−0.081	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

C17orf75–COAD

Open the COAD breakdown →