C17orf64

Across TCGA patient cohorts, C17orf64 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C17orf64-associated genes across cancer lineages are ERK2, mTOR_pS2448, and Src_pY527. Each is linked with C17orf64 in more than 1 cancer types. Because this analysis shows association rather than direction, both C17orf64-to-partner and partner-to-C17orf64 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by C17orf64-low versus C17orf64-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C17orf64→partner) and Y-score (partner→C17orf64) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.225	+2.222	.006	.011	3	2
UCEC	mTOR_pS2448 →	-0.143	-3.156	.023	.018	3	2
UCEC	Src_pY527 →	-0.404	-3.159	.027	.019	3	2
UCEC	A-Raf_pS299 →	-0.113	-3.459	.026	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.178	-2.459	.012	.019	3	1
UCEC	MEK1 →	+0.464	+2.906	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ERK2 by C17orf64 expression — UCEC

Explore this box plot interactively →