C17orf49

Across TCGA patient cohorts, C17orf49 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C17orf49-associated genes across cancer lineages are PCNA, VHL, and mTOR_pS2448. Each is linked with C17orf49 in more than 1 cancer types. Because this analysis shows association rather than direction, both C17orf49-to-partner and partner-to-C17orf49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by C17orf49-low versus C17orf49-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C17orf49→partner) and Y-score (partner→C17orf49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.271	+3.000	.029	.037	3	1
UCEC	VHL →	-1.060	-3.000	.006	.037	3	1
UCEC	mTOR_pS2448 →	-0.191	-3.000	.026	.037	2	1
UCEC	JNK_pT183_Y185 →	-0.227	-2.986	.019	.037	1	1
UCEC	p27_pT198 →	+0.147	+3.000	.017	.037	1	1
UCEC	Caspase-8 →	-0.305	-3.000	.035	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PCNA by C17orf49 expression — UCEC

Explore this box plot interactively →