C17orf100

Across TCGA pan-cancer cohorts, C17orf100 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated C17orf100 data layer compared with 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher C17orf100 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C17orf100 expression acts as an unfavorable survival marker, although some lineages such as UVM and LGG show a favorable association.

UVM, ACC, and LGG are the cancer types where C17orf100 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.826	0.412	<.001	111	view →
ACC	DFS	Median	II,III,IV	0.203	0.625	<.001	89	view →
LGG	OS	Median	All	0.599	0.402	<.001	36	view →
BRCA	OS	Tertile	III,IV	0.873	0.711	.005	34	view →
PAAD	DFS	Tertile	All	0.356	0.144	.005	26	view →
UCS	OS	Quartile	III,IV	0.640	0.221	.017	18	view →
SCLC	OS	Tertile	II,III,IV	0.860	0.555	.011	16	view →
ESCA	DFS	Tertile	All	0.886	0.320	.008	16	view →
READ	DFS	Quartile	III,IV	0.709	0.287	.009	16	view →
OV	OS	Median	All	0.874	0.805	.021	14	view →
DLBC	DFS	Tertile	All	0.621	1.000	.004	13	view →
MESO	OS	Median	II,III,IV	0.744	0.301	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

C17orf100–UVM (OS)

Open the UVM breakdown →