C16orf89

Across TCGA patient cohorts, C16orf89 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C16orf89-associated genes across cancer lineages are EGFR, MEK1, and PCNA. Each is linked with C16orf89 in more than 1 cancer types. Because this analysis shows association rather than direction, both C16orf89-to-partner and partner-to-C16orf89 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by C16orf89-low versus C16orf89-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf89→partner) and Y-score (partner→C16orf89) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.214	-2.321	.001	.006	3	1
UCEC	MEK1 →	+0.364	+2.459	.016	.019	3	1
UCEC	PCNA →	+0.212	+2.321	.017	.006	3	1
UCEC	PR →	-0.208	-3.169	.045	.018	3	1
UCEC	Rab25 →	-0.336	-2.584	.014	.010	3	1
UCEC	Annexin-1 →	+0.636	+2.459	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR by C16orf89 expression — UCEC

Explore this box plot interactively →