C16orf89

Across TCGA cell cohorts, C16orf89 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible C16orf89-associated genes across cancer lineages are CST5, OR1M1, and GLOD5. Each is linked with C16orf89 in more than 1 cancer types. Because this analysis shows association rather than direction, both C16orf89-to-partner and partner-to-C16orf89 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST5 grouped by C16orf89-low versus C16orf89-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf89→partner) and Y-score (partner→C16orf89) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CST5 →	+0.880	+4.099	<.001	.001	3	1
SKIN	OR1M1 →	+0.011	+4.022	<.001	.006	3	1
SKIN	GLOD5 →	+0.080	+3.632	<.001	.003	3	1
SKIN	CATSPER4 →	+0.046	+3.882	<.001	.001	3	1
SKIN	SPDYC →	+0.517	+3.196	<.001	.007	3	1
SKIN	TP53TG3E →	+0.340	+3.347	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CST5 by C16orf89 expression — SKIN

Explore this box plot interactively →