C16orf86

Across TCGA patient cohorts, C16orf86 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C16orf86-associated genes across cancer lineages are JNK2, MEK1, and PCNA. Each is linked with C16orf86 in more than 1 cancer types. Because this analysis shows association rather than direction, both C16orf86-to-partner and partner-to-C16orf86 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by C16orf86-low versus C16orf86-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf86→partner) and Y-score (partner→C16orf86) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.523	+2.834	<.001	.034	3	1
UCEC	MEK1 →	+0.537	+3.000	.011	.037	3	1
UCEC	PCNA →	+0.315	+3.000	.011	.037	3	1
UCEC	beta-Catenin →	+0.649	+3.000	.026	.037	3	1
UCEC	c-Met_pY1235 →	+0.088	+3.009	.041	.019	3	1
UCEC	AR →	-0.453	-3.000	.036	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

JNK2 by C16orf86 expression — UCEC

Explore this box plot interactively →