C16orf78

Across TCGA patient cohorts, C16orf78 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C16orf78-associated genes across cancer lineages are Annexin-1, JNK2, and MEK1. Each is linked with C16orf78 in more than 2 cancer types. Because this analysis shows association rather than direction, both C16orf78-to-partner and partner-to-C16orf78 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by C16orf78-low versus C16orf78-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf78→partner) and Y-score (partner→C16orf78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.897	+2.479	<.001	.010	3	3
UCEC	JNK2 →	+0.226	+2.000	.011	.032	3	2
UCEC	MEK1 →	+0.447	+2.459	.006	.019	3	2
SKCM	MYH11 →	-0.841	-3.000	.029	.035	2	2
SKCM	Smad4 →	+0.104	+2.841	.039	.033	3	1
SKCM	CD49b →	+0.396	+3.169	<.001	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Annexin-1 by C16orf78 expression — UCEC

Explore this box plot interactively →