C16orf70

Across TCGA pan-cancer cohorts, C16orf70 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C16orf70 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher C16orf70 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C16orf70 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

LSCC, COAD, and LUAD are the cancer types where C16orf70 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	III,IV	0.527	0.884	.010	25	view →
COAD	DFS	Median	II,III,IV	0.846	1.000	.030	6	view →
LUAD	OS	Median	III,IV	0.750	0.998	.025	5	view →
GBM	OS	Median	All	0.894	0.816	.038	4	view →
UCEC	DFS	Tertile	II,III,IV	0.519	0.926	.049	4	view →
CCRCC	DFS	Quartile	II,III,IV	0.759	0.424	.040	1	view →
HNSC	DFS	Quartile	II,III,IV	0.452	0.750	.013	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C16orf70–LSCC (OS)

Open the LSCC breakdown →