C16orf70

Across TCGA patient cohorts, C16orf70 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C16orf70-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and EGFR. Each is linked with C16orf70 in more than 1 cancer types. Because this analysis shows association rather than direction, both C16orf70-to-partner and partner-to-C16orf70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by C16orf70-low versus C16orf70-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf70→partner) and Y-score (partner→C16orf70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.345	+3.321	.004	.009	3	2
UCEC	EGFR_pY1068 →	-0.188	-2.662	.046	<.001	3	1
UCEC	EGFR →	-0.143	-1.415	.017	.046	3	1
UCEC	eIF4E →	+0.157	+1.765	.047	.014	3	1
UCEC	eIF4G →	+0.321	+2.222	.005	.010	3	1
UCEC	A-Raf_pS299 →	-0.146	-2.807	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

p62 Lck ligand by C16orf70 expression — UCEC

Explore this box plot interactively →