C14orf93

Across TCGA patient cohorts, C14orf93 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C14orf93-associated genes across cancer lineages are MSH2, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with C14orf93 in more than 1 cancer types. Because this analysis shows association rather than direction, both C14orf93-to-partner and partner-to-C14orf93 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by C14orf93-low versus C14orf93-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C14orf93→partner) and Y-score (partner→C14orf93) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.224	-2.295	.018	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.776	+3.341	.001	.005	3	2
UCEC	14-3-3_beta →	-0.095	-2.973	.022	.035	3	1
UCEC	EGFR_pY1068 →	-0.248	-2.321	.016	.034	3	1
UCEC	A-Raf_pS299 →	-0.138	-3.169	.005	.018	3	1
UCEC	Heregulin →	-0.111	-2.986	.029	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MSH2 by C14orf93 expression — UCEC

Explore this box plot interactively →