C14orf39

Across TCGA patient cohorts, C14orf39 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C14orf39-associated genes across cancer lineages are FoxM1, GAPDH, and Ku80. Each is linked with C14orf39 in more than 1 cancer types. Because this analysis shows association rather than direction, both C14orf39-to-partner and partner-to-C14orf39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by C14orf39-low versus C14orf39-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C14orf39→partner) and Y-score (partner→C14orf39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.255	+1.736	.004	.007	3	2
UCEC	GAPDH →	+0.432	+2.000	.020	.029	3	2
UCEC	Ku80 →	+0.229	+1.750	.005	.004	3	2
UCEC	PKC-delta_pS664 →	-0.112	-2.807	.006	.002	3	2
UCEC	Rab25 →	-0.397	-2.115	<.001	.016	3	2
UCEC	TFRC →	+0.553	+1.440	.002	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

FoxM1 by C14orf39 expression — UCEC

Explore this box plot interactively →