Across TCGA patient cohorts, C14orf178 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C14orf178-associated genes across cancer lineages are Ku80, MEK1, and Rictor_pT1135. Each is linked with C14orf178 in more than 1 cancer types. Because this analysis shows association rather than direction, both C14orf178-to-partner and partner-to-C14orf178 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C14orf178→partner) and Y-score (partner→C14orf178) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.275	+2.183	.026	.035	3	1
UCEC	MEK1 →	+0.445	+3.321	.020	.010	3	1
UCEC	Rictor_pT1135 →	-0.127	-3.321	.017	.010	3	1
UCEC	PCNA →	+0.275	+3.321	.015	.010	2	1
UCEC	Caspase-8 →	-0.279	-3.000	.034	.036	2	1
UCEC	Notch1 →	+0.252	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

C14orf178 survival (RNA) · tumor vs normal (RNA) · all C14orf178 data types