Across TCGA patient cohorts, C12orf77 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf77-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4G. Each is linked with C12orf77 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf77-to-partner and partner-to-C12orf77 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf77→partner) and Y-score (partner→C12orf77) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.143	-3.143	.003	.018	3	1
UCEC	EGFR_pY1068 →	-0.321	-2.459	.008	.020	3	1
UCEC	eIF4G →	+0.295	+2.459	.049	.020	3	1
UCEC	ERK2 →	+0.265	+2.459	.004	.020	3	1
UCEC	Heregulin →	-0.153	-2.321	.010	.034	3	1
UCEC	MEK1 →	+0.428	+3.459	.015	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

C12orf77 survival (RNA) · tumor vs normal (RNA) · all C12orf77 data types