Across TCGA pan-cancer cohorts, C12orf73 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C12orf73 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C12orf73 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C12orf73 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where C12orf73 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.296	1.000	.006	42	view →
LSCC	DFS	Quartile	II,III,IV	0.797	0.243	.003	25	view →
CCRCC	DFS	Median	All	0.961	0.869	.034	1	view →
LUAD	DFS	Quartile	All	0.447	0.800	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: C12orf73 tumor-vs-normal RNA expression · all C12orf73 data types