C12orf66

Across TCGA pan-cancer cohorts, C12orf66 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated C12orf66 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher C12orf66 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated C12orf66 expression acts as an unfavorable survival marker.

SKCM and OV are the cancer types where C12orf66 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	0.130	0.692	<.001	16	view →
OV	DFS	Median	All	0.142	0.541	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

C12orf66–SKCM (DFS)

Open the SKCM breakdown →