C12orf66

Across TCGA patient cohorts, C12orf66 protein abundance is significantly associated with the RNA expression of many other genes, with 4,104 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible C12orf66-associated genes across cancer lineages are EZH2, SLC1A2, and RFC2. Each is linked with C12orf66 in more than 2 cancer types. Because this analysis shows association rather than direction, both C12orf66-to-partner and partner-to-C12orf66 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C12orf66 versus EZH2 in GBM, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf66→partner) and Y-score (partner→C12orf66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EZH2 →	-0.765	-0.201	.002	.004	3	3
PDAC	SLC1A2 →	+1.122	+0.360	<.001	<.001	3	3
UCEC	RFC2 →	-0.723	-0.276	.001	.002	3	3
GBM	DBF4 →	-0.663	-0.233	<.001	.001	3	3
GBM	CLSPN →	-0.729	-0.187	<.001	.001	3	3
BRCA	TCF3 →	-0.580	-0.472	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,104 associations by consensus.

C12orf66 vs EZH2 — GBM

Explore this scatter interactively →